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連絡先担当者 Mr. Ryan
Youyistrett 368 No, Shijiazhuang, Hebei
CAS#: *********0
Chemical Formula: C*8H*3N7O2
Exact Mass: **9.****7
Molecular Weight: **9.****2
Elemental Analysis: C, *7.*1; H, 6.*6; N, *9.*2; O, 6.*0
AZD***1 is an irreversible inhibitor of mutant EGFR kinase with IC*0 values of *5nM, *7nM and **0nM, respectively for L**8R/T**0M, ex*9del and wildtype EGFR [1].
A series of mutations cause the resistance of EGFR, AZD***1 is developed for an irreversible and selective inhibitor of the mutant EGFR. AZD***1 binds to the ATP binding site of EGFR by targeting Cys **7. In EGFR recombinant enzyme assay, AZD***1 shows about **0 times greater potency against the mutant EGFR than wildtype EGFR. AZD***1 does not exhibit significant activity towards other receptor kinase. In vitro assays show that AZD***1can inhibit EGFR phosphorylation with lower IC*0 value in cell lines harboring sensitising EGFR mutants than in wildtype cell lines. Additionally, AZD***1 can induce profound shrinkage in mutant EGFR at low doses in xenograft models. This also happens in transgenic mouse tumor models. Mice treated with AZD***1 at the dose of 5 mg/kg/day display *0% reduction in tumor volume
国: | China |
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离岸价格: | Get Latest Price |
ロケーション: | - |
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製品グループ : | alkaloid oncology medicine |