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AZD3759 cas no 1626387-80-1

China

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タイトルまたは説明

Chemical Information

Product Name AZD3759
Iupac Chemical Name (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate 
Synonyms AZD-3759;AZD3759;AZD 3759 
Molecular Formula C22H23ClFN5O3 
Molecular Weight 459.90 
Smile COC1=C(OC(N2[C@H](C)CN(C)CC2)=O)C=C3C(N=CN=C3NC4=CC=CC(Cl)=C4F)=C1
InChiKey MXDSJQHFFDGFDK-CYBMUJFWSA-N
InChi InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
Cas 1626387-80-1

Technical Data

Appearance off-white solid 
Purity 99% by HPLC 
Solubility Soluble in DMSO 
Storage 3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping Condition Shipped under ambient temperature 
Quality control    HNMR HPLC         

Description

AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types

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Wuhan Sun-shine Bio-technology Corporation Limited

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Wuhan Sun-shine Bio-technology Corporation Limited

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Wuhan, Other, China,

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