タイトルまたは説明

First recognized in Japanese food Natto, gamma-poly-glutamic acid (γ-PGA) is a nutural multifunctional biopolymer produced with Baccillus Subtilis by fermentation. Gamma PGA is a water soluble homo-polyamide. It consists of D- and L-glutamic acid monomers which are connected by amide linkages between α-amino and γ-carboxyl group. Freda has three series of cosmetics grade PGA products- the high molecule (HM) PGA (*******0K Da), low molecule (LM) PGA (*****0k Da) and ultra low molecule (ULM) PGA (***0k Da).



Large number of carboxyl groups along the molecule chain of gamma PGA can form hydrogen bonding in a molecule or between different molecules. Thus it has high water absorbability and moisture-retaning capability. Thanks to its unique properties, Gamma PGA can be used as thickener, filmogen, humcctant, retarder, cosolvent, binder and anti-freezer, therefore the application prospect of gamma PGA is promosing.



Efficacy of Gamma PGA in Cosmetics



Long lasting moisturization



With strong moisturizing ability, the side chain of gamma PGA can enhance the moisturizing capability of skin without breaking the moisturize balance of skin. When integrated into skin-care products, gamma PGA can strengthen the moisturizing ability of skin and prevent skin from drying.



 

The higher the molecule weight, the stronger the winding effect between molecules. As the molecule network becomes larger, a gamma PGA elastic film will be formed on the surface of skin.

Due to its unique molecule structure, gamma PGA (HM) can absorb and retain skin moisture efficiently adn form a silky film on the surface of skin. It can effectively prevent the skin from long-time drying condition, especially in air-conditioned rooms or in cold dry winter. Gamma PGA enhances skin smoothness, reduces wrinkles and improves elasticity of skin.

The compound of gamma PGA (HM) and gamma PGA (LM) has better moisturizing efficacy. Gmma PGA (HM) can form a protective film on the surface of skin to prevent loss of moisturize. Meanwhile, gamma PGA(LM) can nourish skin to deep layer by locking more moisture and nutrients. As shown in Fig.4, adding 3 ‰ of compound gamma PGA HM and LM at a ratio of 1:1 can enhance the moisturizing effect and synergistically improve the effect of active ingredients in facial cream. Fig. 5 shows gamma PGA(HM) can effectively improve skin humidity and elasticity.



 

Synergy Effect

Moisture is a key factor to keep the skin healthy. Gamma PGA can not only efficiently increase the moisture of skin but participate in the metabolic activity of skin to improve the health condition of skin.

Increasing and maintaining HA of skin

As a basic component of skin, Hyaluronic Acid (HA) can lock the moisture of skin and maintain its elasticity, but HA can be hydrolyzed very quickly by hyaluronidase (HAase) of skin as well. Gamma PGA can increase and maintain HA in the skin. Fig.6 illustrates how gamma PGA inhibits the activity of HAase and increases and manintains HA in skin. Especially, gamma PGA (LM) can effecticely inhibit the HAase in skin. The HA content is remarkably increased for the higher concentration of gamma PGA(LM). It shows that gamma PGA(LM) and HA can improve skin moisture, elasticity and skin appearance in a synergistic manner.

Effectively Increasing NMF in Inner Skin

As a hrgroscopic material produced by skin, Natural Moisturizing Factor (NMF) provides moisture for skin in cuticle. The NMF including amino acids which are hydrolyzed from skin matrix protein (e.g. Filament aggreating protein), pyrrolidone carboxylic acid (PCA), lactic acid and urocanic acid (UCA) can retain moisture of skin. Fig.8 illustrates how PGA (LM) increases the production of NMF which further enhances the internal moisturizing ability of skin.

Gamma PGA is the only effective ingredient that is known till now to induce the production of NMF to **0% of the normal level. Gamma PGA can lock the moisture in inner skin by promoting the growth of fibroblast and increasing the content of NMF in horn cells.

 

Improving Nutrient Supply

Thanks to its controlled release property, gamma PGA can control the release of nutrients and moisture in a continuous manner. Each gamma PGA monomer has ionized groups like α-COOH，-CO and -NH, which can absorb electropositive nutrients (see Fig.*0). Hence a good embedding delievery syetem is created and active ingredients in cosmetics can possibly maximize their efficacy.

Healthy Whitening Efficacy

Gamma PGA can also whiten skin by controlling melanin synthesis to prevent and reduce freckles. Ultraviolet irradiation is the main incentive of trrosinase, which in turn induces the formaiton of Melanin. Table 1 illustrates the inhibition effect of gamma PGA, Kojic acid and VA on tyrosinase. As it shows, gamma PGA, either HM gamma PGA (0.5%) or LM gamma PGA (0.5%) can effectively inhibit the formaiton of melanin. Meanwhile, gamma PGA can form a film upon surface of skin which fences out ultraviolet.

 

As a multifunctional skin-care ingredient, gamma PGA can moisturize and whiten skin and improve skin health. It builds gentle and tender skin and restore skin cells, facilitates exfoliation of of old keratin, clears stagnant melanin and gives birth to white and translucent skin.
 

Safety Concern
 

Freda cosmetics grade gamma PGA meets USP/NF standards, with TPC≤**0cfu/g, Staphylococcus aureus tested negative and yeast and mold ≤**0cfu/g. It is suitable for all kinds of cosmetics and personal care applications with no safety concern.
 

Applications of Gamma PGA in Skin-care Products
 

Gmma PGA has excellent compatibility in non-ionic, anionic and amphoteric surfactants. It is a perfect ingredient for cream, essence, astringent, face mask, eye gel, sun cream, shampoo, body wash, lotion, hairystyle formula and so on.
 

Flexbility in Formula
 

Gamma PGA is an ideal moistutizer with high compatibility with other cosmetics materials. Dosage of the material depends on the function of skin-care products. Generally suggested dosage of gamma PGA (HM) is 1‰*1%. Gamma PGA (HM) is more suitable for anti-wrinkle, UV-preventing and moisturizing strengthening products, suggested dosage is 1‰*1%. Gamma PGA (LM) is better for facial masks and whitening products thanks to its nutrition transdermal absorption and melanin inhibition effect, and the suggested dosage is 3‰ã€‚
 

Shandong Freda Biotechnology Co.,Ltd is dedicated to the R&D, manufacture and sales of green food additives(natamycin, nisin), Natural cosmetic ingredients (γ-PGA, pullulan ). It has established a modern and advanced industrial base in Linyi, Shandong Province, occupying **0,**0 m2. The company has passed  ISO***1, ISO****0 quality management system, and is certified by US FDA, COSMOS,Halal, Kosher, etc.

In the spirit of  'Innovative Technology, Health Pilot', Freda will actively rise to challenges ahead in the market, provide differentiated technical solutions and establish long-term and win-win partnership with clients from across the world.