タイトルまたは説明

Production Name:Shikimic acid
Basic Information:
CAS:*******0

Formula:  C7H*0O5
Molecular weight:  **4.*5
Appearance:  white powder / crystal
Purity: *8%
Used Part: Fruit
Storage:  in tightly closed container under cool, dry and well-ventilated shelter away from light and source of ignition

Shelf life:  *4 months min.

Usage:
 

In the pharmaceutical industry, shikimic acid from the Chinese star anise(Illicium verum) is used as a base material for production of oseltamivir(Tamiflu). Although shikimic acid is present in most autotrophic organisms, it is a biosynthetic intermediate and in general found in very low concentrations. The low isolation yield of shikimic acid from the Chinese star anise is blamed for the ***5 shortage of oseltamivir. Shikimic acid can also be extracted from the seeds of the sweetgum fruit, which is abundant in North America, in yields of around 1.5%. For example, 4 kg of sweetgum seeds is needed for fourteen packages of Tamiflu. By comparison, star anise has been reported to yield 3 to 7% shikimic acid. Biosynthetic pathways in E.coli have recently been enhanced to allow the organism to accumulate enough material to be used commercially.

Protecting groups are more commonly used in small-scale laboratory work and initial development than in industrial production processes because their use adds additional steps and material costs to the process. However, the availability of a cheap chiral building block can overcome these additional costs e.g. shikimic acid for oseltamivir.