タイトルまたは説明
Alex
Functions Of
Hyaluronan
Until the late ***0s, hyaluronan was
described as a "goo" molecule, a ubiquitous carbohydrate polymer
that is part of the extracellular matrix. For example, hyaluronan
is a major component of the synovial fluid, and was found to
increase the viscosity of the fluid. Along with lubricin, it is one
of the fluid's main lubricating
components.
Hyaluronan is an important component
of articular cartilage, where it is present as a coat around each
cell (chondrocyte). When aggrecan monomers bind to hyaluronan in
the presence of link protein, large, highly negatively charged
aggregates form. These aggregates imbibe water and are responsible
for the resilience of cartilage (its resistance to compression).
The molecular weight (size) of hyaluronan in cartilage decreases
with age, but the amount increases.
Hyaluronan is also a major component
of skin, where it is involved in tissue repair. When skin is
exposed to excessive UVB rays, it becomes inflamed (sunburn) and
the cells in the dermis stop producing as much hyaluronan, and
increase the rate of its degradation. Hyaluronan degradation
products then accumulate in the skin after UV
exposure.
While it is abundant in extracellular
matrices, hyaluronan also contributes to tissue hydrodynamics,
movement and proliferation of cells, and participates in a number
of cell surface receptor interactions, notably those including its
primary receptors, CD*4 and RHAMM. Upregulation of CD*4 itself is
widely accepted as a marker of cell activation in lymphocytes.
Hyaluronan's contribution to tumor growth may be due to its
interaction with CD*4. Receptor CD*4 participates in cell adhesion
interactions required by tumor
cells.
Although hyaluronan binds to receptor
CD*4, there is evidence hyaluronan degradation products transduce
their inflammatory signal through toll-like receptor 2 (TLR2), TLR4
or both TLR2, and TLR4 in macrophages and dendritic cells. TLR and
hyaluronan play a role in innate
immunity.
High concentrations of hyaluronan in
the brains of young rats, and reduced concentrations in the brains
of adult rats suggest hyaluronan plays an important role in brain
development.
| 国: |
China |
| モデル番号: |
cosmetic grade
|
| 离岸价格: |
300 ~ 500 / Kilogram （交渉可能）
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|
| ロケーション: |
- |
| 最低注文量の価格: |
300 per Kilogram |
| 最低注文量: |
1 Kilogram |
| パッケージの詳細: |
ikg/bag |
| 納期: |
3days |
| 供給能力: |
1000 Kilogram per Month |
| 支払いタイプ: |
Other, PayPal, Money Gram, Western Union, D/P, D/A, L/C, T/T |
| 製品グループ : |
cosmetic grade
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