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Ibrutinib-biotin

离岸价格

Get Latest Price

0 ~ 1125 USD ( Negotiable )

5 Milligram Minimum Order

国:

China

モデル番号:

离岸价格:

0 ~ 1125 USD ( Negotiable )（交渉可能） Get Latest Price

ロケーション:

最低注文量の価格:

最低注文量:

5 Milligram

パッケージの詳細:

納期:

供給能力:

100 Milligram

支払いタイプ:

L/C

製品グループ :

今すぐお問い合わせください

Hangzhou Guangyuan Biotechnologies Co.,LTD

China

無料会員

連絡先担当者 RaystarBio

Hangzhou, Zhejiang

今すぐお問い合わせください

製品仕様

Storage:Powder,-20Â°C,2 years;DMSO solution,4Â°C

タイトルまたは説明

Biological Activity(Only for Reference)

Description

Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO*********8A1 Compound **5, has an IC*0 of 0.****1.*2 nM for BTK.

Targets

BTK	TEC	BLK	BMX	LCK)	ITK
0.***1.2 nM[1]	1.**2.9 nM[1]	3.**4.7 nM[1]	4.**5.7 nM[1]	5.**6.2 nM[1]	0.**0.8 μM[1]

In vitro

Ibrutinib-biotin (Compound **5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin**-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells[1].

In vivo

Chemical Information

CAS No.	***********4
Formula	C6H0N*2O9S
Molecular Weight	**7.7
Storage	Powder,0°C,2 years;DMSO solution,4°C,2 weeks;DMSO solution,0°C,6 months

Protocol

Kinase Assay:[1]

Kinase Assay

In this study, assay formats are tested for sensitivity, specificity, range, and to determine most suitable anti BTK Antibody. An aliquot of DOHH2 cell lysate (1 mg/mL) is inhibited with 1 μM Ibrutinib then labeled with probe (1 μM). Negative controls: Untreated DOHH2 and Jurkat cell lysates (l mg/mL) are labeled with probe (1 μM) and Untreated DOHH2 cell lysate. Standard Streptavidin plate (*-pack); Read Buffer T (*0 mL), SULFO TAG Goat Anti-mouse (*0 μg); SULFO TAG Goat Anti-rabbit (*0 μg); SULFO TAG streptavidin (*0 ug); MSD Standard Plates; MSD Blocker A; Protease inhibitor cocktail; Positive Control lysates from BTK expressing cell line (DOHH2); Negative Control lysates; Ibrutinib (PCI); probe compound **5 (biotinylated probe).

Cell Research:

Cell line
Concerntration
Incubation Time
Method

Animal Research:

Animal Models
Formulation
Dosages
Administration

国:	China
モデル番号:	-
离岸价格:	0 ~ 1125 ( Negotiable ) （交渉可能） Get Latest Price
ロケーション:	-
最低注文量の価格:	-
最低注文量:	5 Milligram
パッケージの詳細:	-
納期:	-
供給能力:	100 Milligram
支払いタイプ:	L/C
製品グループ :	-