Instruction

Lincomycin hydrochloride injection is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis (fam. Streptomycetaceae). It is a white, or practically white, crystalline powder and is odourless or has a faint odour. Its solutions are acid and are dextrorotatory. Lincomycin hydrochloride injectionis freely soluble in water, soluble in dimethylformamide and very slightly soluble in acetone. 

Lincomycin hydrochloride injectionInjection is a clear, colourless or almost colourless solution, practically free from particles. 

 

Dosage and administration

Note: If significant diarrhoea occurs during therapy, this antibiotic should be discontinued .

Lincomycin hydrochloride injectionis incompatible with novobiocin, kanamycin and phenytoin. 

With beta-haemolytic streptococcal infections, treatment should continue for at least *0 days to diminish the likelihood of subsequent rheumatic fever or glomerulonephritis. 

Intramuscular 

Adults: 

Serious infections - **0 mg (2 mL) intramuscularly every *4 hours. 

More serious infections - **0 mg (2 mL) intramuscularly every *2 hours or more often, as determined by the severity of the infection. 

Children over 1 month of age: 

Serious infections - one intramuscular injection of *0 mg/kg/day. 

More serious infections - one intramuscular injection of *0 mg/kg every *2 hours or more often. 

Intravenous 

Intravenous doses are given on the basis of 1 g Lincomycin hydrochloride injectiondiluted in not less than **0 mL of appropriate solution and infused over a period of not less than one hour. Note: Severe cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate. 

Adults: 

Serious infections - **0 mg to 1 g given every ***2 hours. 

More severe infections - the above doses may be increased. In life-threatening situations, daily intravenous doses of as much as 8 g have been given. 

Children over 1 month of age: 

Depending on the severity of the infection, ****0 mg/kg/day may be infused in divided doses as described in the table below. 

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