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masitinib API

离岸价格

Get Latest Price

( Negotiable )

|

100 Gram Minimum Order

国:

China

モデル番号:

TUM-2

离岸价格:

( Negotiable ) Get Latest Price

ロケーション:

china

最低注文量の価格:

-

最低注文量:

100 Gram

パッケージの詳細:

Aluminum foil bag, PTFE Bottle, or meet your requirment

納期:

Within one week

供給能力:

10 Kilogram per Month

支払いタイプ:

T/T, L/C, D/P

製品グループ :

今すぐお問い合わせください
無料会員

連絡先担当者 Mr. James

Building A, NO.688,Qiushi Road,Jinshan District, Shanghai, shanghai

今すぐお問い合わせください

製品仕様

  • Other Names: masitinib
  • Type: Pharmaceutical Intermediates
  • Purity (%): 99%
  • Application: Anti-tumor API
  • Appearance: white powder

タイトルまたは説明

In vitro, masitinib had greater activity and selectivity against KIT than imatinib, inhibiting recombinant human wild-type KIT with an half inhibitory concentration (IC(*0)) of **0+/**0 nM and blocking stem cell factor-induced proliferation and KIT tyrosine phosphorylation with an IC(*0) of **0+/**0 nM in Ba/F3 cells expressing human or mouse wild-type KIT. Masitinib also potently inhibited recombinant PDGFR and the intracellular kinase Lyn, and to a lesser extent, fibroblast growth factor receptor 3. In contrast, masitinib demonstrated weak inhibition of ABL and c-Fms and was inactive against a variety of other tyrosine and serine/threonine kinases. This highly selective nature of masitinib suggests that it will exhibit a better safety profile than other tyrosine kinase inhibitors; indeed, masitinib-induced cardiotoxicity or genotoxicity has not been observed in animal studies. Molecular modelling and kinetic analysis suggest a different mode of binding than imatinib, and masitinib more strongly inhibited degranulation, cytokine production, and bone marrow mast cell migration than imatinib. Furthermore, masitinib potently inhibited human and murine KIT with activating mutations in the juxtamembrane domain. In vivo, masitinib blocked tumour growth in mice with subcutaneous grafts of Ba/F3 cells expressing a juxtamembrane KIT mutant.

国: China
モデル番号: TUM-2
离岸价格: ( Negotiable ) Get Latest Price
ロケーション: china
最低注文量の価格: -
最低注文量: 100 Gram
パッケージの詳細: Aluminum foil bag, PTFE Bottle, or meet your requirment
納期: Within one week
供給能力: 10 Kilogram per Month
支払いタイプ: T/T, L/C, D/P
製品グループ : API

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To:

Mr. James < Shanghai Yudiao Chemistry Technology Co., Ltd >

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