タイトルまたは説明

Octenidine Dihydrochloride
Synonym:N,N'-(decane*1,**-diyldipyridin**-yl**-ylidene)dioctan**-amine dihydrochloride
CAS No.: *********6
Molecular Formula:C*6H*2N4  or  C*6H*2N4·2HCl
Molecular Weight: **3.***2
Appearance:White powder
Packaging:1kg  5kg  *5kg
Expiration:2 years
Application:Personal care, Medical
Introduction:
Octenidine dihydrochloride is a topical antimicrobial used in personal care and medical industry. It is similar in its action to the quaternary ammonium compounds (quats), but is of somewhat broader spectrum of activity.
Octenidine is currently increasingly used in continental Europe as a substitute for quats or chlorhexidine (with respect to its slow action and concerns about the carcinogenic impurity *-chloroaniline) in water- or alcohol-based skin, mucosa and wound antiseptics. In aqueous formulations, it is often potentiated with addition of *-phenoxyethanol.  
As topical antimicrobial agents, Octenidine is typically used for skin, mu­cous membrane and open wound decontamination. Octenidine meets the need for a broad-spectrum antimicrobial suitable for wound care.   
First launched in the UK during ***0, octenidine is available in three formulations in the UK: octenilin® wound gel (0.*5% octenidine); octenilin® wound irrigation solution (0.*5% octenidine); and octenisan® wash lotion (0.3% octenidine) for decolonisation.   
Octenidine is more active than 4% chlorhexidine against S aureus, Staphylococcus epidermidis, Proteus mirabilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli  and Candida albicans, etc.   
At concentrations of <1.5μM, octenidine reduced numbers of these bacteria by *9% within *5 minutes. However, the wound environment may modify bacteriological potency recorded in culture: 8% serum reduces the effectiveness of chlorhexidine between 2.5 and **-fold. In vitro, the addition of pus or *5% blood reduces chlorhexidines effectiveness by around *-log step. In contrast, blood (up to *0%), albumin and mucin do not undermine octenidines efficacy. This observation suggests that products containing octenidine retain antibacterial efficacy when applied to wounds.