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国:
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モデル番号:
T0616
离岸价格:
200 / Kilogram Get Latest Price
ロケーション:
China
最低注文量の価格:
200 per Kilogram
最低注文量:
1 Kilogram
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steel can, glass bottle
納期:
as arrange
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60000 Kilogram per Year
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L/C, T/T
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連絡先担当者 Ms. helen
Yunxi Industrial zone Yueyang city, Hunan province, China., Yueyang, Hunan
Titanocene dichloride is the organotitanium compound with
the formula (η*-C5H5)2TiCl2, commonly abbreviated as Cp2TiCl2. This
metallocene is a common reagent in organometallic and organic
synthesis. It exists as a bright red solid that slowly hydrolyzes
in air.[1] Cp2TiCl2 does not adopt the typical "sandwich" structure
like ferrocene due to the 4 ligands around the metal centre, but
rather takes on a distorted tetrahedral shape
Preparation
cp2TiCl2 is a generally useful
reagent that effectively behaves as a source of Cp2Ti2+. A large
range of nucleophiles will displace chloride. Examples:
Cp2TiCl2 continues to be prepared from titanium tetrachloride, in the same way as its original synthesis by Wilkinson and Birmingham:[3]
2 NaC5H5 + TiCl4 → (C5H5)2TiCl2 + 2 NaClThe reaction is conducted in THF. Work-up sometimes washing with hydrochloric acid to convert hydrolysis derivatives to the dichloride. Recrystallization from toluene forms acicular crystals.
Cp2TiCl2 can also be prepared by using freshly distilled
cyclopentadiene:
This reaction is conducted under a nitrogen atmosphere and by using THF as solvent. The product is purified by soxhlet extraction using toluene as solvent.[4]
The complex is pseudotetrahedral. Each of the two Cp rings are
attached as η5 ligands. Viewing
the Cp ligands as tridentate, the complex has a coordination number of 8.
Applications in organic synthesis
Reactions
Cp2TiCl2 undergoes anion exchange reactions, e.g. to
give the pseudohalides. With NaSH and with polysulfide salts, one
obtains the sulfido derivatives Cp2Ti(SH)2 and Cp2TiS5.
One Cp ligand can be removed from Cp2TiCl2 to give tetrahedral
CpTiCl3. This conversion can be effected by with TiCl4 or by
reaction with SOCl2.[5]
Ti(II) derivatives
cp2TiCl2 is a precursor to many Ti(II) derivatives. Titanocene,
TiCp2, is itself so highly reactive that it is not known but it can
be trapped by conducting the reduction in the presence of ligands.
Reduction of titanocene dichloride results in the fulvalene complex
shown in the figure.[citation
needed]
Reductions have been investigated using Grignard reagent and alkyl lithium compounds. More conveniently handled reductants include Mg, Al, or Zn. The following syntheses demonstrate some of the compounds that can be generated by reduction of titanocene dichloride in the presence of π acceptor ligands.[6]
Cp2TiCl2 + 2 CO + Mg → Cp2Ti(CO)2With only one equivalent of reducing agent, Ti(III) species result, i.e. Cp2TiCl.
Alkyne and benzyne derivatives of titanocene are well known.[7] One family of derivatives are the titanocyclopentadienes.[8]
Titanocene equivalents react with alkenyl alkynes followed by carbonylation and hydrolysis to form bicyclic cyclopentadienones, related to the Pauson-Khand reaction).[9] A similar reaction is the reductive cyclization of enones to form the corresponding alcohol in a stereoselective manner.[*0]
Reduction of titanocene dichloride in the presence of conjugated
dienes such as 1,*-butadiene gives η*-allyltitanium
complexes.[*1] Related reactions occur
with diynes. Furthermore, titanocene can catalyze C-C bond
metathesis to form asymmetric
diynes.[8]
Derivatives of (C5Me5)2TiCl2
The closest relative to titanocene-ethylene complex is that
derived by Na reduction of (C5Me5)2TiCl2 in the presence of
ethylene. The Cp compound cannot be made. This pentamethylcyclopentadienyl (Cp*) species
undergoes many reactions such as cycloadditions of
alkynes.[7]
Medicinal uses
Titanocene dichloride was investigated as a anticancer
drug.[*2] The
mechanism by which it acts is not understood, but some conjecture
that it might be due to its interactions with the protein
Titanocene dichloride
transferrin.[*3] IUPAC name[hide] dichloridobis (η*-
cyclopentadienyl) titanium Other names[hide] titanocene dichloride,
dichlorobis(cyclopentadienyl)titanium(IV) Identifiers CAS number ********8 RTECS
number XR******0 Properties Molecular formula C*0H*0Cl2Ti Molar mass **8.*6 g/mol Appearance bright
red solid Density 1.*0 g/cm3,
solid Melting point **9
°C
国: | China |
モデル番号: | T0616 |
离岸价格: | 200 / Kilogram Get Latest Price |
ロケーション: | China |
最低注文量の価格: | 200 per Kilogram |
最低注文量: | 1 Kilogram |
パッケージの詳細: | steel can, glass bottle |
納期: | as arrange |
供給能力: | 60000 Kilogram per Year |
支払いタイプ: | L/C, T/T |
製品グループ : | - |