Polymyxin B sulfate is one of a group of related antibiotics derived from Bacillus polymyxa. The polymyxins are rapidly bactericidal, this action being exclusively against gram-negative bacteria.

The broad-spectrum effectiveness of Terramycin against both gram-positive and gram-negative organisms is enhanced by the particular effectiveness of polymyxin B against infections associated with gram-negative organisms, especially those due to Pseudomonas aeruginosa, where polymyxin B is the antibiotic of choice. In addition, there is evidence to indicate that polymyxin B sulfate possesses some antifungal activity. The combined antibacterial effect of Terramycin plus polymyxin is at least additive and, in many instances, an actual synergistic action is obtained.

Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is a suspension of oxytetracycline hydrochloride and polymyxin B sulfate in a special petrolatum base. Each gram of ointment contains oxytetracycline HCl equivalent to 5 mg of oxytetracycline and 10,000 units of polymyxin B as the sulfate.

ADMINISTRATION: Terramycin Ophthalmic Ointment with Polymyxin B Sulfate should be administered topically to the eye 24 times daily.

PRECAUTIONS: Allergic reactions may occasionally occur. Treatment should be discontinued if reactions are severe.
Note: The use of oxytetracycline and other antibiotics may result in an overgrowth of resistant organisms such as Monilia, staphylococci, and other species of bacteria. If new infections due to nonsensitive bacteria or fungi appear during therapy, appropriate measures should be taken.

RECOMMENDED STORAGE: Store below 25°C (77°F).

License by Pfizer 
License Date:03.1959 
Place of Production Istanbul-Turkey