Description
EINECS No.: ********5
Melting Point : **8~**4 ?
Solubility: Soluble in water,and slightly in
alcohol.
Appearance: White to whitish crystal powder,
oderless and tasteless.
Pharmacology Action: Galanthamine extract is
specific, competitive and reversible acetylcholinesterase
inhibitor. It is also an allosteric modulator at nicotinic
cholinergic receptor sites potentiating cholinergic nicotinic
neurotransmission. Both the acetylcholine and nicotine receptors
have been suggested as areas related to cognitive impairment.
Initially, Galanthamine extract was used in anesthesiology to
antagonize the effects of non-depolarizing muscle relaxants, and
since then it was rapidly introduced in other areas of medicine,
i.e. neurology, ophthalmology, gastroenterology, intensive care and
resuscitation, cardiology, physiotherapy.
Galanthamine extract is a product with broad therapeutic index,
allowing "soft" manifestation of its effect with individual dosing
depending on the particular case.
Several trials already showed that Galantamine *6 and *4 mg/day
significantly benefits the cognitive, functional, and behavioral
symptoms of AD as compared with placebo and proved also to be very
effective in symptomatic treatment of senile dementia of
Alzheimer's type.
