Piroctone Olamine

Description

Kopirox is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp. It is often used in shampoo as a replacement of commonly used Zinc Pyrithione. It is used over *0 years in the personal care formulations and also used as preservative and thickening agent.

Hair shedding and hair thinning have been reported to be affected by dandruff and seborrheic dermatitis. In a comparative clinical study, it was demonstrated that Piroctone Olamine outperformed Ketoconazole and zinc pyrithione based shampoo in its ability to increase hair shaft diameter in androgenic alopecia. Piroctone Olamine also reduced sebum production. 

Piroctone Olamine is the ethanolamine salt of the hydroxamic acid derivative of piroctone.

*-Hydroxy*4methyl**-(2,4,*-trimethylpentyl)*2(1H) pyridinone, *-aminoethanol salt