Description
Clobetasol propionate
Category dermatology drugs - corticosteroids
Other names Chlorine betamethasone acetate, propionate , chlorine
training he Faso, especially skin , anthracene skin ,
beclomethasone loose, clobetasol propionate , betamethasone
dipropionate chlorine , especially skin , propionic acid chlorine
times betamethasone
Formula C*5H*2ClFO5
Molecular Weight **6.*7
CAS No. *********7
Content *8.****2 %
Standard Level USP*2
Melting point about **6 ° C
Specific rotation **8 - ***4 ° C
Appearance white crystalline powder
description:Clobetasol propionate is a corticosteroid used to treat
various skin disorders including eczema and psoriasis. It is also
highly effective for contact dermatitis caused by exposure to
poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV)
of the corticosteroids, making it one of the most potent available.
It comes in shampoo, mousse, ointment and emollient cream
presentations. It has very high potency and typically should not be
used with occlusive dressings, or for extended continuous use
(beyond two weeks). It is also used to treat several auto-immune
diseases including alopecia areata, vitiligo and lichen planus
(auto immune skin nodules).
Purpose
1 , clobetasol propionate is a synthetic glucocorticoid efficient
topical drugs . Has strong anti-inflammatory, anti- itching and
capillary contraction, its anti-inflammatory effect of
approximately **2.5 times hydrocortisone , betamethasone sodium
phosphate , 2.3 times , *8.7 times fluocinolone . Also inhibit cell
mitosis , can effectively penetrate into the stratum corneum .
2 , topical for chronic eczema , neurodermatitis , psoriasis
, palmoplantar pustulosis , lichen planus , discoid lupus
erythematosus and other corticosteroids, topical treatment is
effective for itching and non-infectious inflammatory skin disease
.
3 , anti-inflammatory, anti-allergic, anti-proliferative ,
immunosuppressive effects .
Compound products available ketoconazole . Miconazole nitrate
, Vitamin A acid cream and liniment to do .
Packaging foil bag aluminum listen
Pharmacology and toxicology the role of the product quickly ,
is highly effective clinical application of topical corticosteroids
in a strong efficacy . Has a strong capillary contraction, its
anti-inflammatory effects of hydrocortisone **2.5 times ,
betamethasone sodium phosphate 2.3 times *8.7 times fluocinolone .
Systemic adverse reactions fluocinolone 3 times , no sodium
retention effect , there are certain to promote sodium and
potassium excretion .
Pharmacokinetics This product is available through intact skin
after topical absorption . After absorption of corticosteroids
given with the system in the body metabolism , are primarily
metabolized in the liver , excreted by the kidneys .
Dosage external, thin layer evenly applied to the affected
area **2 times daily . In addition to the palms, and plantar
keratosis lesions hypertrophy , in general, should not be used
packet treatment. 1 week dosage should not exceed *0g.
Formulations and specifications clobetasol propionate
ointment â‘ 0.*5%, *0g 5mg; â‘¡ 0.*2%, *0g 2mg.
Adverse reactions
1 can be produced in drug site erythema , burning, itching and
other irritation, even can cause contact dermatitis.
(2) there may be long-term topical local telangiectasia ,
hirsutism, skin atrophy, wound healing disorders, makes the skin
prone to secondary infections , and fungal infections such as
folliculitis , packet treatment more likely.
3 Long-term foreign used for facial acne-like rash can occur ,
rosacea -like dermatitis , facial erythema , perioral
dermatitis.
4 Long-term foreign to the skin folds , such as the medial femoral
stretch marks can occur , especially in adolescents prone .
5 long-term , large-scale use may be due to the cumulative
absorption of drugs , there glucocorticoid -induced systemic
reactions , there Cushing\'s syndrome , manifested as hirsutism,
acne, moon face, hypertension, osteoporosis , depression , and poor
wound healing . Long-term use can inhibit the growth and
development of children .
Contraindications
1 primary bacterial , fungal and viral infections such as skin
diseases, such as impetigo, ringworm , jock itch , herpes simplex
and other disabled.
(2) and matrix components of the drug allergies or other
corticosteroid allergy.
Pregnant and lactating women pregnant and lactating women
should be weighed against the caution. Pregnant women can not be
long-term , large-scale or large-scale use .
Pediatric Use Infants and children should not be used.
Drug interactions not clear.
Note
1 This product is not a large area or long-term topical . A large
area, not more than two weeks , in order to avoid systemic
absorption caused reversible hypothalamic - pituitary - adrenal
axis suppression .
(2) can not be applied to the face, armpits, groin and other
skin delicate parts . Even short-term use can also cause adverse
reactions such as skin atrophy .
Three pregnant women , lactating women should consider the
pros and cons medication , use caution. Pregnant women can not be
long-term , large-scale or large-scale use .
4 infants and children should not be used .
5 This product is not available for the eye .
6 if accompanied by a skin infection , you must also use
anti-infectives. Such as simultaneous use, infection symptoms do
not improve in time , the drug should be discontinued until the
infection is controlled.
exw Price : $***0/KG
