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Description

 

In animals, following oral administration, atrazine is rapidly and completely metabolised, primarily by oxidative dealkylation of amino group, and by reaction of the chlorine atom with endogenous thiols.Diaminochlorotriazine is the main primary metabolite, which readily conjugates with glutathione. More than *0% of the dose is eliminated in the urine and around *3% in the faeces within *4h.

 

In tolerant plants, atrazine is readily metabolised to hydroxyatrazine and amino acid conjugates, with further decomposition of hydroxyatrazine by degradation of the side-chains and hydrolysis of the resulting amino acids on the ring., together with evolution of CO*2. In sensitive plants, unaltered atrazine accumulates, leading to chlorosis and death. Major metabolites under all conditions are desethylatrazine and hydroxyatrazine.