Sharp spike vented (for bottles & bags) and non-vented (for plastic bottles) for better penetration. ISO *****4 compliant spike, ISO **4/1 & ISO **4/2 compliant end-connection. Superior quality of latex tubing/flash bulb for self-sealing. **0 micron filter and standard size surface area (*0 sq. cm). Specially designed roller clamp for better flow control. Top quality needle. Available with or without air-vent. Non-Toxic, Pyrogen Free & Sterile by EO.