Description

We offer Sodium Propionate Commercial Pure and Pharmacopoeia Grades

Sodium Propionate Commercial Food Grade & Pure

Sodium Propionate

CH3CH2COONa
C3H5NaO2 Formula wt *6.*6
INS: **1 CAS: [*******6]

DESCRIPTION
Sodium Propionate occurs as white or colorless, transparent crystals or as a granular, crystalline powder. It is hygroscopic in moist air. One gram is soluble in about 1 mL of water at *5°, in about 0.*5 mL of boiling water, and in about *4 mL of alcohol. The pH of a 1:*0 aqueous solution is between 8.0 and *0.5.
Function: Preservative; mold inhibitor.

REQUIREMENTS
Identification:
A. A 1:*0 aqueous solution gives positive tests for Sodium.
B. Upon ignition, a sample yields an alkaline residue that effervesces with acids.
C. Warm a small sample with sulfuric acid. Propionic acid, recognized by its odor, evolves.
Assay: Not less than *9.0% and not more than **0.5% of C3H5NaO2 after drying.
Alkalinity (as Na2CO3): Passes test (about 0.*5%).
Iron: Not more than 0.**3%.
Lead: Not more than 2 mg/kg.
Water: Not more than 1%.

Sodium Propionate BP British Pharmacopoeia

C3H5NaO2
*6.1 *- *******6
Action and use
Antifungal

DEFINITION
Sodium propionate
Content
*9.0 per cent to **1.0 per cent Sodium propionate (dried substance).

CHARACTERS
Appearance
Colourless crystals or, white or almost white powder, slightly hygroscopic.
Solubility
Freely soluble in water, sparingly soluble in alcohol, practically insoluble in methylene chloride.

IDENTIFICATION
First identification A, D.
Second identification B, C, D.
A. Infrared absorption spectrophotometry.
Comparison reference spectrum of sodium propionate.
B. Dissolve 0.1 g in a mixture of 2 ml of copper sulphate solution and 2 ml of methylene chloride. Shake vigorously and allow to stand. Both the upper and the lower layer show a blue colour.
C. To 5 ml of solution S add 2 ml of 0.1 M silver nitrate. A white precipitate is formed.
D. Solution S gives reaction of sodium.

TESTS
Solution S
Dissolve *0 g Sodium propionate in carbon dioxide-free water prepared from distilled water and dilute to **0 ml with the same solvent.
Appearance of solution
Solution S is clear and colourless.
pH
7.8 to 9.2
Dilute 1 ml of solution S to 5 ml with water.
Related substances
Liquid chromatography.
Test solution: Dissolve 0.**0 g of the substance to be examined in water and dilute to **0 ml with the same solvent.
Reference solution (a) Dissolve *0 mg of the substance to be examined and *0 mg of sodium acetate in water and dilute to **0 ml with the same solvent.
Reference solution (b) Dilute 1.0 ml of the test solution to **0 ml with water.
Column: ı
ı— size: l= 0.*5 m, = 4.6 mm;
ı— stationary phase: octadecylsilyl silica gel for chromatography (5μm).
Mobile phase Dilute 1 ml of phosphoric acid R to ***0 ml with water.
Flow rateı1 ml/min.
Detection Spectrophotometer at **0 nm.
Injectionı*0 μl.
System suitability Reference solution (a):
ı— resolution: minimum 5 between the peaks due to sodium acetate and sodium propionate.
Limits:
ı— any impurity: not more than 0.1 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.1 per cent);
ı— total: not more than half the area of the principal peak in the chromatogram obtained with reference solution (b) (0.5 per cent);
ı— disregard limit: 0.*5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.*5 per cent).
Readily oxidizable substances
In a ground-glass-stoppered conical flask introduce *0 g of the substance ( Sodium propionate.) to be examined.
Add **0 ml of water R and stir to dissolve. Add *5 ml of sodium hypobromite solution and *0 ml of a **0 g/l solution of sodium acetate, stopper the flask and allow to stand for *5 min. Add *0 ml of potassium iodide solution and *0 ml of hydrochloric acid  while cooling.
Titrate with 0.2 M sodium thiosulphate, adding 2 ml of starch solution R towards the end of the titration. Carry out a blank titration. The difference between the volumes used in the 2 titrations is not greater than 2.2 ml.
Iron
Maximum *0 ppm.
*0 ml of solution S complies with the limit test for iron.
Heavy metals
Maximum *0 ppm.
*2 ml of solution S complies with limit test A. Prepare the standard using lead standard solution (1 ppm Pb).
Loss on drying
Maximum 0.5 per cent, determined on 1.**0 g by heating in an oven at **5C for 3 h.

ASSAY
Dissolve *0.0 mg Sodium propionate in *0 ml of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
1 ml of 0.1 M perchloric acid is equivalent to 9.*1 mg of C3H5NaO2.

Sodium Propionate FCC Food Grade as per Food Chemical Codex

Sodium Propionate

CH3CH2COONa
C3H5NaO2 Formula wt *6.*6
INS: **1 CAS: [*******6]

DESCRIPTION
Sodium Propionate occurs as white or colorless, transparent crystals or as a granular, crystalline powder. It is hygroscopic in moist air. One gram is soluble in about 1 mL of water at *5°, in about 0.*5 mL of boiling water, and in about *4 mL of alcohol. The pH of a 1:*0 aqueous solution is between 8.0 and *0.5.
Function: Preservative; mold inhibitor.

REQUIREMENTS
Identification:
A. A 1:*0 aqueous solution gives positive tests for Sodium.
B. Upon ignition, a sample yields an alkaline residue that effervesces with acids.
C. Warm a small sample with sulfuric acid. Propionic acid, recognized by its odor, evolves.
Assay: Not less than *9.0% and not more than **0.5% of C3H5NaO2 after drying.
Alkalinity (as Na2CO3): Passes test (about 0.*5%).
Iron: Not more than 0.**3%.
Lead: Not more than 2 mg/kg.
Water: Not more than 1%.

Sodium Propionate NF USP

Sodium Propionate
C3H5NaO2·xH2O
Propanoic acid, sodium salt, hydrate.
Sodium propionate hydrate [********0]
Anhydrous *6.*6 [*******6]
Sodium Propionate, dried at **5 for 2 hours, contains not less than *9.0 percent and not more than **0.5 percent of C3H5NaO2.

Identification—
A: Infrared Absorption **7K , on un-dried specimen.
B: A solution (1 in *0) responds to the tests for Sodium.
Alkalinity— Dissolve 2.0 g in *0 mL of water, and add phenolphthalein TS: if a pink color is produced, it is discharged by 0.*0 mL of 0.*0 N sulfuric acid.
Water: not more than 1.0%.
Heavy metals— Dissolve 2 g in 1 mL of 1 N acetic acid and sufficient water to make *5 mL: the limit is 0.**1%.
Organic volatile impurities: meets the requirements.
(Official until July 1, ***7)
Assay— Dissolve about **0 mg of Sodium Propionate, previously dried at **5 for 2 hours and accurately weighed, in *0 mL of glacial acetic acid. Add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 9.**6 mg of C3H5NaO2.