Organic Tocofersolan, D-alpha-tocopherol Acid Polyethylene Glycol 1000 Succinate (tpgs)

Description

APPLICATIONSofVITAMIN E TPGS
Emulsifier - TPGS has amphiphilc properties and is therefore used as emulsifier for nutraceuticals and pharmaceuticals (Lehr ***5). Emulsifier for injectable formulations
DRUG DELIVERY SYSTEM
· Drug solubilizer It directly increases the bioavailability and delivery of poorly soluble drugs
· Protects drugs from crystallization Provide Vitamin E or poorly soluble nutraceuticals in liquid dosage form Reduces drug sensitivity on skin and tissues
· Acts as a vehicle in semi-dosage form and also for pulmonary (inhalation) dosage form
· Carrier for wound care and treatment
· A thermal binder in melt granulations / extrusion process
ABSORPTION ENHANCER
ANTIOXIDANT
Vehicle for lipid - based drug delivery - Vitamin E TPGS is an important extension to a range of drug delivery products
Source of natural Vitamin E - used in pharmaceutical formulations as well as dietary supplements Extensively used in solid, topical and ophthalmic dosage forms
AMPHIPHILIC (SURFACE-ACTIVE) PROPERTIES
Vitamin E TPGS is amphiphile, that is it has a dual nature. Part of the molecule exhibits hydrophilicity and the other lipophilicity. General accepted view is that the polyethylene glycol portion serves as the hydrophilic polar head (water soluble), while the tocopherol succinate portion serves as the lipophilic alkyl tail (water insoluble).