Best price pyroglutamic acid CAS 98-79-3 l-pyroglutamic acid

Description

1) Product Name: Best price pyroglutamic acid CAS ******3 l-pyroglutamic acid

2) Active ingredients:  l-pyroglutamic acid

3) Specification: ≥*9%

4) Test method:  TLC

5) Appearance:  white crystalline powder

6) Introduction:

Pyroglutamic acid (also known as PCA, *-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.

It is a metabolite in the glutathione cycle that is converted to glutamate by *-oxoprolinase.

Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.

Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers:

(2R) or D which happens to be (+) or d
(2S) or L which happens to be () or l