タイトルまたは説明

1.Product profile:

Name:SAMe

Other name:S-Adenosyl-L-methionine

CAS: *********2

Molecular Formula: C*5H*2N6O5S 

Appearance:  White crystal powder

Specification: *8%min

2.Function:

1)S-Adenosyl methionine (SAMe) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAMe. Although these anabolic reactions occur throughout the body, most SAMe is produced and consumed in the liver.

2)The methyl group (CH3) attached to the methionine sulfur atom in SAMe is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than *0 metabolic reactions involve the transfer of a methyl group from SAMe to various substrates such as nucleic acids, proteins, and lipids.

3)In bacteria, SAMe is bound by the SAMe riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.The reactions that produce, consume, and regenerate SAMe are called the SAMe cycle. In the first step of this cycle, the SAMe-dependent methylases (EC 2.1.1) that use SAMe as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from *-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.*3 or EC 2.1.1.*4). This methionine can then be converted back to SAMe, completing the cycle.

4)Another major role of SAMe is in polyamine biosynthesis. Here, SAMe is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.*0) to form S-adenosyl*5'**-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

5)SAMe is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

About US
 

Xian Lyphar Biotech Co.LTD is a professionally managed biotech company exclusively into the manufacturing, marketing and exporting of plant extracts and health care products,founded in ***1.

There are *5 experts in our research team. We insist in innovation and produce high quality products.At the same time, we have two sales department as well as more than *0 teams to put our products sell to all over the world.

We have a strong research and development team, as well as the laboratory equipped with complete.Such as high performance liquid chromatography, gas chromatography, spectrophotometer, atomic absorption spectrometry, rotation, automatic titrator, bod incubator, chemical oxygen demand (cod) incubator, melting point instrument and etc.

Our business is based on the basis of honesty and trustworthy,continuously surpass,realize a winwin situation.We sincerely invite you both at home and abroad to strengthen communication and cooperation.